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Key Concept #2: The Clues to Optimal Gene Expression Are Found in Evolution

Hey all.


Did you know?


While we can’t sit at a control panel and fiddle with our gene expression like a mad scientist just yet, we can make some very good guesses based on a powerful heuristic: human evolution.

Reason being, two million years of selection pressure exerted upon the hominid line designed a healthy, successful, productive, vibrant organism.

We didn’t just “happen,” after all. We look like we do and work like we do and have the genes that we do that express themselves the way that they do because of very powerful selection pressures.



The habitats in which we lived, the foods we ate, the movements we had to perform in order to survive, the sunlight to which we were exposed, the stressors we faced – these environmental factors shaped our genetic code, and it is to these various environmental stimuli that our genetic expression responds most favourably.

The clues to realizing our Primal Blueprint lies scattered amidst our evolutionary history.

Until that day when we can sit a computer terminal and decide which genes we want to express today, and how, the best we can probably do is use human evolution as a base level tool for making lifestyle decisions.

You’ll probably refine the details later, but evolution is a darn good place to start.


Mark Sisson



Every small change WILL become a

big difference in your life.



With so much love,​

Katie Jane

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